Characterization of the FKBP·Rapamycin·FRB Ternary Complex [J. Am. Chem. Soc.2005,127, 4715−4721].

y J . Am . Chem . Soc . 136 : 6453 − 6462

Cross-dehydrogenative coupling reactions between -ketoesters and electron-rich arenes, such as indoles, proceed with high regiochemical fidelity with a range of -ketoesters and indoles. The mechanism of the reaction between a prototypical ketoester, ethyl 2-oxocyclopentanonecarboxylate and N-methylindole, has been studied experimentally by monitoring the temporal course of the reaction by 1 ...

Characterization of the FKBP.rapamycin.FRB ternary complex.

Rapamycin is an important immunosuppressant, a possible anticancer therapeutic, and a widely used research tool. Essential to its various functions is its ability to bind simultaneously to two different proteins, FKBP and mTOR. Despite its widespread use, a thorough analysis of the interactions between FKBP, rapamycin, and the rapamycin-binding domain of mTOR, FRB, is lacking. To probe the affi...

Am J

The repellency and insecticidal efficacy of Nopikex®, a soap formulation containing 20% diethyl toluamide and 0.5% permethrin, was evaluated against a laboratory colony of phlebotomine sand flies (Lutzomya longipalpis). The repellency of Nopikex soap was also compared with that of a placebo soap against another species (Lu. Youngi) in a forest near Tulua, Valle del Cauca, Colombia. In laborator...

Am J Clin Nutr

Microsoft Word - Wang J Biol Chem Revised

From Key Laboratory of Photosynthesis and Molecular Environment Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China , Institute of Molecular Cell Biology, Hebei Normal University, Shijiazhuang, Hebei Province, 050016, China, and Department of Plant Biology, College of Biological Sciences,...